… activation we have analysed the processing of pro-caspase-7 by serine proteases with varied
specificities… The caspase-7 zymogen was rapidly activated by granzyme B and more slowly …

… 1 In the past years it has become clear that a group of cysteinyl aspartate-specific … Activation
of pro-caspase-7 by serine proteases includs a non-canonical specificity. Biochem J 1997; …

… Using this method, we obtained specific activities that are 17–… that pro-caspase 7 mutant
LEHD/NDTA was activated by … location has considerable impact on the efficacy of activation…

… elegans and CED-4 protein is the stimulator for CED-3 activation while the CED-9 protein is
… zymogens and contain long pro-domains which allow them to interact with specific signalling …

… More recently, it has been suggested that serine proteases … AP24, a chymotrypsin-like
serine protease, is activated by a … specific and potent irreversible inhibitors of serine proteases. …

… region of procaspase-7. This suggested a possible cooperative mechanism of cleavage
and … Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. …

… , refers to the number specific for the particular caspase. In addition, we have included in …
caspases in a mechanistic sense closer to serine proteases, in particular those of the subtilisin …

… on the activation of cellular proteases. Elucidation of the specific proteases involved in …
Key components of these granules are perforin and the granzyme family of serine proteases…

… For full activation, an additional, still unknown serine protease has to intervene. Only the
combined action of both proteases … specificity at aspartic acid is not strictly required for caspase …

… pro‐A‐SMase zymogen at the non‐canonical cleavage site after … It is presently unknown how
A‐SMase and pro‐caspase‐7 … has to be distinguished from the mere catalytic specificity for …